Human Gut Derived BAs

The human gut houses the largest and most diverse population of microbes among the body’s many organs. Secondary bile acids are produced in the terminal ileum, the caecum, and the upper colon through deconjugation, dehydroxylation, oxidation, isopropylation, desulfurization, and esterification. Bile salt hydrolyase induces deconjugation and 7α-hydroxysteroid dehydrogenase induces dehydroxylation, which are the two most important reactions in the process to make gut derived secondary bile acids.

ICE Pharma are delighted to offer the most comprehensive human gut derived product range which will be extended as new gut derived bile acids are discovered. These include iso bile acids, allo bile acids and microbially conjugated bile acids along with keto (oxo) derivatives too.

ICE720 3,7-diketo-allo-cholanic acid

ICE725 allo-ursodeoxycholic acid

ICE746 allo-iso-chenodeoxycholic acid

ICE747 allo-iso-ursodeoxycholic acid

ICE870 3-keto-chol-4-enic acid

ICE894 7b-hydroxy-3-keto-chol-4-enic acid

ICE907 3-keto-4,6-choladienoic acid

ICE908 Ursodeoxycholylphenylalanine

ICE909 Ursodeoxycholyltyrosine

ICE910 Ursodeoxycholylleucine

ICE911 Glycoisoursodeoxycholic acid

ICE913 Glycoursodeoxycholic acid

ICE941 Sodium deoxycholate

ICE943 Glycocholic acid

ICE944 Sodium taurodeoxycholate

ICE945 Sodium glycocholate

ICE946 Sodium cholate

ICE947 Tauroursodeoxycholic acid

ICE948 Sodium Glycodeoxycholate

ICE949 Sodium Dehydrocholate

ICE950 Sodium Chenodeoxycholate

ICE952 Sodium Lithocholate

ICE957 N-(3a-hydroxy-7-keto-5b-cholanoyl)glycine

ICE958 Glycochenodeoxycholic acid

ICE959 Glycodeoxycholic acid