Human Gut Derived BAs

The human gut houses the largest and most diverse population of microbes among the body’s many organs. Secondary bile acids are produced in the terminal ileum, the caecum, and the upper colon through deconjugation, dehydroxylation, oxidation, isopropylation, desulfurization, and esterification. Bile salt hydrolyase induces deconjugation and 7α-hydroxysteroid dehydrogenase induces dehydroxylation, which are the two most important reactions in the process to make gut derived secondary bile acids.

ICE Pharma are delighted to offer the most comprehensive human gut derived product range which will be extended as new gut derived bile acids are discovered. These include iso bile acids, allo bile acids and microbially conjugated bile acids along with keto (oxo) derivatives too.

ICE001 Cholic acid

ICE005 Chenodeoxycholic acid

ICE006 7-keto lithocholic acid

ICE007 Ursodeoxycholic acid

ICE008 Deoxycholic acid

ICE013 3-keto chenodeoxycholic acid

ICE014 3,7-diketocholanic acid

ICE020 Hyodeoxycholic acid

ICE021 Sodium Hyodeoxycholate

ICE029 Lithocholic acid

ICE033 3-keto litocholic acid

ICE043 3-keto allo-litocholic acid

ICE044 iso-lithocholic acid

ICE045 allo-lithocholic acid

ICE046 allo-iso-lithocholic acid

ICE054 Sodium taurocholate

ICE088 iso-chenodeoxycholic acid

ICE092 7-keto-isocholic acid

ICE093 Ursocholic acid

ICE140 Sodium taurochenodeoxycholate

ICE286 Sodium tauroursodeoxycholate

ICE629 3-keto ursodeoxycholic acid

ICE715 7-keto iso-lithocholic acid

ICE717 3-keto-allo-chenodeoxycholic acid

ICE718 3-keto-allo-ursodeoxycholic acid